How do you administer IV ganciclovir?
Caution: Ganciclovir must be administered by intravenous infusion over 1 hour at a concentration not exceeding 10 mg/mL. Do not administer by rapid or bolus intravenous injection because the resulting excessive plasma levels may increase the toxicity of ganciclovir.
How do you reconstitute ganciclovir?
Reconstitute vial with 10 ml of Sterile Water for Injection (do not use bacteriostatic water), and shake well to dissolve drug. Vial stability: stable at room temperature for 12 hours (Do not refrigerate). Remember when further diluted with NS or D5W, final solution should be refrigerated until ready for use.
Is Valganciclovir the same as ganciclovir?
Valganciclovir, an oral prodrug that is rapidly converted to ganciclovir, also plays a major role in the treatment and prevention of CMV infections in immunocompromised hosts.
Is ganciclovir toxic?
Ganciclovir is known to have hematological toxicity, neurotoxicity, and possibly hepatotoxicity (21). Hematological toxicity has been characterized in vitro on normal human hematopoietic progenitor cells.
What is the cost of cytovene?
The cost for Cytovene intravenous powder for injection 500 mg is around $134 for a supply of 1 powder for injection, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.
How do you administer foscarnet?
Method of administration: Foscarnet should be administered by the intravenous route only, either by a central venous line or in a peripheral vein. When peripheral veins are used, the solution of foscarnet 24 mg/ml must be diluted.
Does Ganciclovir cause neutropenia?
However, both Ganciclovir and the CMV infection itself can cause marrow toxicity, notably neutropenia, that may consequently expose these immunosuppressed patients to life-threatening bacterial and/or fungal infections.
What is the brand name for Ganciclovir?
Ganciclovir implant (Vitrasert) is used to treat cytomegalovirus (CMV) infection of the eye.
What class drug is ganciclovir?
Ganciclovir is in a class of medications called antivirals. It works by preventing the spread of CMV disease or slowing the growth of CMV.
Is ganciclovir a chemo drug?
Conclusions: Ganciclovir is the only antiviral chemotherapy which reduces the risk of CMV infection or disease after most types of major transplantation.
How do you prepare ganciclovir sodium equivalent to 500 mg?
Each 10 mL clear glass vial contains ganciclovir sodium equivalent to 500 mg of ganciclovir and 46 mg of sodium. The contents of the vial should be prepared for administration in the following manner: 1. Reconstitute lyophilized CYTOVENE-IV by injecting 10 mL of Sterile Water for Injection, USP, into the vial.
What is the brand name for ganciclovir?
16 DESCRIPTION 17 Ganciclovir is a synthetic guanine derivative active against cytomegalovirus (CMV). 18 CYTOVENE-IV is the brand name for ganciclovir sodium for injection. 19 CYTOVENE-IV is available as sterile lyophilized powder in strength of 500 mg per vial 20 for intravenous administration only.
Why should I take ganciclovir capsules with food?
It is important that you take ganciclovir capsules with food. This is to make sure the medicine is fully absorbed into the body and will work properly. To get the best results, ganciclovir must be given for the full time of treatment. Also, this medicine works best when there is a constant amount in the blood.
What is the usual dose of ganciclovir for cytomegalovirus?
The usual dose of intravenous ganciclovir for the initial treatment of CMV is 5 mg / kg every 12 hours for 14 to 21 days. To prevent a relapse of CMV, the usual dose is 5 mg / kg once daily every day of the week, or 6 mg / kg once daily 5 days a week.
