What do Annexins do?

Annexins can function as scaffolding proteins to anchor other proteins to the cell membrane. Annexins assemble as trimers, where this trimer formation is facilitated by calcium influx and efficient membrane binding. This trimer assembly is often stabilized by other membrane-bound annexin cores in the vicinity.

How many protein sequences are there?

Studies of the protein universe as it exists today began with the first determination of a protein sequence by Sanger in 1952 (2). Now, there are almost 8 million sequences in a nonredundant (NR) database of protein sequences, including the complete genomes of ≈1,800 different species.

What is the CD95 pathway?

CD95 is a surface receptor that has the capacity to mediate apoptosis induction in cancer cells. To induce apoptosis, CD95 recruits a number of proapoptotic factors including caspase-8 to form the death-inducing signaling complex when stimulated by CD95 ligand (CD95L).

Is annexin V an antibody?

Annexin V Antibody recognizes endogenous levels of total annexin V protein. This antibody is not predicted to cross-react with other annexin family members.

How do you determine protein sequence?

The two major direct methods of protein sequencing are mass spectrometry and Edman degradation using a protein sequenator (sequencer). Mass spectrometry methods are now the most widely used for protein sequencing and identification but Edman degradation remains a valuable tool for characterizing a protein’s N-terminus.

What is UniProt database?

The Universal Protein Resource (UniProt) is a comprehensive resource for protein sequence and annotation data. The UniProt databases are the UniProt Knowledgebase (UniProtKB), the UniProt Reference Clusters (UniRef), and the UniProt Archive (UniParc).

What is the ANXA2 gene?

ANXA2 (Annexin A2) is a Protein Coding gene. Diseases associated with ANXA2 include Acute Promyelocytic Leukemia and Keloid Formation.

What is the function of annexin A2?

“Annexin A2 is a C-terminal PCSK9-binding protein that regulates endogenous low density lipoprotein receptor levels.” Cited for: FUNCTION, INTERACTION WITH PCSK9, MUTAGENESIS OF 77-ARG–LYS-81; 80-LYS–ALA-84 AND LYS-88. “Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation.”

How does Annexin A2 interact with PCSK9?

“Annexin A2 reduces PCSK9 protein levels via a translational mechanism and interacts with the M1 and M2 domains of PCSK9.” Cited for: FUNCTION, INTERACTION WITH PCSK9, RNA-BINDING. It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis.