What is serotonin syndrome (SS)?

A potentially lethal condition, serotonin syndrome (SS) is caused most often when certain antidepressant agents are taken concurrently with other drugs that modulate synaptic serotonin levels. 1,2 When patients take two or more antidepressants from different pharmacologic classes, drug-drug interactions may occur; these interactions may lead to

Are there any illegal drugs associated with serotonin syndrome?

Certain illegal drugs and dietary supplements also are associated with serotonin syndrome. Serotonin is a chemical your body produces that’s needed for your nerve cells and brain to function. But too much serotonin causes symptoms that can range from mild (shivering and diarrhea) to severe (muscle rigidity, fever and seizures).

What is the hallmark finding in serotonin syndrome?

The hallmark finding in serotonin syndrome is clonus and hyperreflexia, generally most prominent in the legs. Clonus is usually inducible, meaning that it is triggered by the examiner (video above). In severe cases, clonus may occur spontaneously. This can resemble a seizure.

What are the causes of drug induced serotonin syndrome?

Drug-Induced Serotonin Syndrome 1 Causative Agents. SS may occur when central and peripheral serotonin receptors are overstimulated through the action of antidepressant medications or drugs of abuse. 2 Clinical Signs and Symptoms. 3 Treatment. 4 Role of the Pharmacist.

Is serotonin syndrome a life-threatening drug reaction?

Sign in List of authors. The serotonin syndrome is a potentially life-threatening drug reaction that may result from therapeutic medication use, self-poisoning, or interactions between drugs. Supported in part by a grant from the National Institute on Drug Abuse (DA-14929, to Dr. Boyer).

Does olanzapine cause serotonin syndrome?

Olanzapine and risperidone, atypical antipsychotics, have been paradoxically reported to both induce a serotonin syndrome and to treat this syndrome.9A case report by Haslett and Kumar noted the development of serotonin syndrome after olanzapine was added to a drug regimen of lithium and citalopram.

What is the incidence of serotonin syndrome in the US?

INTRODUCTION The actual incidence of serotonin syndrome is unknown. The number of actual cases is likely much greater than the actual reported cases.