Why does atazanavir cause hyperbilirubinemia?

The cause of the clinical hepatotoxicity from atazanavir is only partially known. The indirect hyperbilirubinemia associated with its use is caused by inhibition of hepatic conjugation of bilirubin, similar to what occurs in Gilbert syndrome and is not indicative of liver injury.

What is the most common side effect of atazanavir?

The most common side effects include: nausea. headache. stomach-area pain.

What does elevated bilirubin indicate?

Elevated levels may indicate liver damage or disease. Higher than normal levels of direct bilirubin in your blood may indicate your liver isn’t clearing bilirubin properly. Elevated levels of indirect bilirubin may indicate other problems.

What is the sequelae of elevated bilirubin?

This yellow coloring is called jaundice. When severe jaundice goes untreated for too long, it can cause a condition called kernicterus. Kernicterus is a type of brain damage that can result from high levels of bilirubin in a baby’s blood. It can cause athetoid cerebral palsy and hearing loss.

What class drug is atazanavir?

Atazanavir is in a class of medications called protease inhibitors. It works by decreasing the amount of HIV in the blood.

What is the meaning of atazanavir?

Medical Definition of atazanavir : a protease inhibitor administered orally in the form of its sulfate C38H52N6O7·H2SO4 in conjunction with other antiretroviral agents in the treatment of HIV infection. Note: Atazanavir is marketed under the trademark Reyataz.

What diseases cause elevated bilirubin?

High total bilirubin may be caused by:

• Anemia.
• Cirrhosis.
• A reaction to a blood transfusion.
• Gilbert syndrome — a common, inherited condition in which there is a deficiency of an enzyme that helps to break down bilirubin.
• Viral hepatitis.
• A reaction to drugs.
• Alcoholic liver disease.
• Gallstones.

What is the ICD 10 code for elevated bilirubin?

Disorder of bilirubin metabolism, unspecified E80. 7 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. The 2022 edition of ICD-10-CM E80. 7 became effective on October 1, 2021.

What levels of serum bilirubin are associated with kernicterus?

Kernicterus, or bilirubin encephalopathy, is bilirubin-induced neurological damage, which is most commonly seen in infants. It occurs when the unconjugated bilirubin (indirect bilirubin) levels cross 25 mg/dL in the blood from any event leading to decreased elimination and increased production of bilirubin.

Is atazanavir an antibiotic?

Is atazanavir (Reyataz) an antibiotic? No, atazanavir (Reyataz) is an antiretroviral medication that is only used for the treatment of HIV. It cannot be used for any infection caused by any other virus or bacteria.

What is atazanavir used for?

Atazanavir is used along with other medications, such as ritonavir (Norvir), to treat human immunodeficiency virus (HIV) infection in adults and children who are at least 3 months of age and weigh at least 22 lb (10 kg). Atazanavir is in a class of medications called protease inhibitors.